Who should be tested?

• Genetic testing is recommended for those with a hereditary renal cell carcinoma syndrome based on any of the following:    
• 1st or 2nd degree relative with RCC diagnosis  
• Diagnosed ≤46 years old 
• Bilateral or multifocal tumors
• Multifocal papillary histology
• HLRSS-associated RCC, RCC with Fumarate hydrtas (FH) deficiency
• BHDS related histology (multiple chromophobe, oncocytoma, oncocytic hybrid)
• Angiomyolipomas of the kidney and one TSC criterion in same person     
• Succinate dehydrogenase (SDH) deficient RCC histologytment eligible

When and what should be tested?

• Upon or before presentation
• Peripheral blood, saliva or buccal mucosa swab

What tests should be considered?

• NCCN/FDA Approved
  • BAP1
  • FLCN
  • FH
  • MET
  • SDHA/B/C/D
  • TSC1, TSC2
  • VHL